Comparative Tabletting behavior of Carbamazepine granules with spherical agglomerated crystals prepared by spherical crystallization technique

The aim of this study was to prepare Spherical agglomerates of Carbamazepine by Quesi-Emulsion Solvent Diffusion system (QESDS) with Ethanol-Chloroform-Water system. Granules were prepared by wet granulation method with different excipients.The prepared agglomerates were evaluated for flowability, compressibility, wettability, packability and solubility. Tablets were prepared and evaluated for tensile strength, hardness, friability, disintegration time and dissolution rate. Formulate, evaluate and compare the tablet dosage form prepared from agglomerated crystals, granules and physical mixture of drug with excipients.The prepared agglomerates were white, free flowing and spherical in shape. The yield of agglomerates was 95% and showed 90-95% drug content. Prepared agglomerates were also improved in compressibility, packability and solubility. The tablet dosage form prepared from agglomerated crystals showed improvements in tensile strength, hardness, friability, disintegration time and dissolution rate as compared to tablets prepared from granules. Thus this technique is simple, less expensive, may be an advantages for developing it on a commercial scale for manufacturing of tablets.